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Vitamin B5

VitB5

Pantothenic Acid - Coenzyme A (CoA) and 4'phosphopanteine

VitB5

Daily Requirement:

Modified DV:

RDA ?:

Adequate Intake ?:

5

true

mg/day

mg/day

Min Deficiency:

Max Toxicity:

Tolerable UL

Animal:Plant Conv:

mg/day

mg/day

mg/day

Date Discovered:

1933

Short Description:

Acyl transfer reactions; acetylation/acylation of proteins, sugars, and other substrates; gene expression. Burning foot syndrome = burning of the feet, neuritis. Major Food Sources: Widespread in foods. AI: 5 mg
Deficiencies are so rare, that most studies do not even study intakes. Toxicity is also extremely rare.

Interpretation:

So common that deficiencies are rare. 

History & Discovery:

Roger J. Williams, an American biochemist discovered pantothenate in 1933 as essential compound for growth of yeast. He called the compound pantothenate, derived from the Greek word pantothen, which translates as "from everywhere", as he found it in literally every food he tested. 

Digestion:


Absorption and Storage:

Jejunum is the Primary Site of Absorption

Two Main Forms


CoA and 4'-phosphopantetheine


About 50% is absorbed


Sodium-dependent multivitamin transporter (SMVT)

Important Pathways:

Pantothenic Acid is used to make CoA.


CoA, alongside FAD, NAD, and TDP, play important roles in pyruvate and alpha-ketoglutarate dehydrogenase, and BCKAD.


CoA plays a role in fat synthesis and oxidation through malonyl-CoA and fatty-acyl CoA.


CoA is important for neurotransmitter and heme synthesis.



Deficiency Diseases, Detection, Cures:

Symptoms:

  • Nausea and vomiting and/or diarrhea

  • Nervous system - general effects

Genetic Diseases:

References:

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