On the 7th August, 1852, M. Alcide Desbouillons wrote to me from Brest, to the effect that his corpulence was a source of great inconvenience; that his duties required him to be much on horseback, and consequently in hot weather he suffered greatly from fatigue. He weighed two hundred pounds, and measured forty-nine inches in circumference. On the 2nd September, after twenty days' trial of my system, and, as he says, perhaps not as rigorously carried out as it should have been, he weighed himself again, and obtained the following result: Weight, one hundred and eighty-nine pounds: circumference, forty-five inches. Twenty days after this he weighed one hundred and eighty-seven pounds, and measured forty-three inches in circumference. This was but a slight difference; yet M. Desbouillons, after the first few days of treatment, could walk with less difficulty, was more active, and was no longer bathed in perspiration. In his last letter he says, "I am continuing your plan of treatment, and expect to find a notable amelioration both in size and weight. The effects produced by your medicine have been in perfect accord with what you had led me to expect. The experiment appears so far conclusive, and I trust that my case will prove thoroughly demonstrative."