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The Clot Thickens: The Enduring Mystery of Heart Disease

Publish date:
November 2, 2021
The Clot Thickens: The Enduring Mystery of Heart Disease

“Malcolm Kendrick's masterly survey of the enduring mystery of heart disease reads like a detective story. With great verve he marshals the evidence for the two main contending theories, exonerates the presumed suspect and makes a formidable case for thrombogenesis (blood clotting) as the perpetrator. Witty, provocative and entertaining, 'The Clot Thickens' packs a powerful scientific punch. Highly recommended.”

Dr James Le Fanu
Doctor, journalist, author of ‘The Rise and Fall of Modern Medicine.’

“Malcolm Kendrick's new book brings to mind the quote from Thomas Huxley when he first learned of Darwin's theory of evolution: ‘how extremely stupid (of me) not to have thought of that’. What Kendrick presents is nothing less than a unifying theory of heart disease, that explains why everything from sickle cell disease to diabetes to a stressful lifestyle increases cardiovascular risk (and he does it with a large dollop of humour). After decades stuck in the blind alley that is the LDL hypothesis, this book is a revelation. It should be read by anyone with even a slight interest in understanding heart disease and what they can do to protect themselves from it.”
Dr Sebastian Rushworth
M.D. Sweden

This is a 150-year detective story with a cast of unrecognised heroes who may, finally, become known for their work on the true causes of heart disease. Exploring the truth about cholesterol - the apparently tried, and convicted, cause of millions of deaths from heart disease - with billions spent each year on lowering cholesterol with diet and drugs.

Is it possible that our villain was simply left holding the gun whilst the true culprits ran and hid? Have they escaped our clutches?

Dr Kendrick also introduces us to a range of other lesser known characters in this tale of selective reporting, data manipulation and intrigue. The true story of heart disease is out there, and the evidence has been brought together here - a scientific mystery for our time that is ready to unfold.

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Heart Disease
Heart disease, also known as cardiovascular disease, refers to a range of conditions that affect the heart and blood vessels. It is a broad term that encompasses various conditions, including coronary artery disease, heart failure, arrhythmias, and valvular heart diseases, among others. Heart disease is a leading cause of death worldwide.
Diet-Heart Hypothesis
The diet-heart hypothesis, also known as the lipid hypothesis, proposes that there is a direct relationship between dietary fat intake, particularly saturated fat and cholesterol, and the development of heart disease. It suggests that consuming high amounts of these fats leads to an increase in blood cholesterol levels, specifically low-density lipoprotein (LDL) cholesterol, which in turn contributes to the formation of atherosclerotic plaques in the arteries. Some consider this hypothesis nothing more than wishful thinking.
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